Early life Transepidermal Water Loss (TEWL) values as a predictor of food allergy and sensitisation at 2 years: results from the BASELINE Study
نویسندگان
چکیده
Rationale Food Allergy is a growing public health concern. There is observational evidence that exposure to food allergens across a disrupted skin barrier can lead to food sensitisation (FS) and food allergy (FA). This mechanism of action has subsequently been proven in murine studies. We sought to ascertain whether a non invasive measurement of skin barrier function at 3 time points in early infancy could predict the development of food sensitisation and allergy in asymptomatic infants enrolled in an unselected prospective birth cohort.
منابع مشابه
Skin barrier impairment at birth predicts food allergy at 2 years of age.
BACKGROUND Transcutaneous exposure to food allergens can lead to food sensitization (FS)/food allergy (FA). We measured skin barrier function in early infancy and related it to the later development of FS/FA at age 2 years. OBJECTIVE We sought to examine the relationship between early life skin barrier function and FA in infancy. METHODS Infants in the Babies After Scope: Evaluating the Lon...
متن کاملNewborn transepidermal water loss values: a reference dataset.
Transepidermal water loss (TEWL) is a simple noninvasive measurement of inside-out skin barrier function. The goal of this research was to establish normal values for TEWL in early life using data gathered from the Cork BASELINE Birth Cohort Study. TEWL was recorded in a standardized fashion using a well-validated open-chamber system. A mean of three readings was recorded from 1,036 neonates (3...
متن کاملO08 - Increased early life Transepidermal Water Loss (TEWL) values can predate atopic dermatitis in asymptomatic infants: results from the BASELINE study
Results The point prevalence of AD in our cohort was 18.7% (299/1597) at 6 months and 15.52% (232/1494) at 12 months. TEWL was lowest at birth, with mean reading 7.32 gwater/m2/hr (±3.33 gwater/m2/hr). It rose between birth and 2 months, mean 10.97 gwater/m2/hr (±7.98 gwater/m2/hr) where it plateaued at 6 months with mean reading 10.71 gwater/m2/hr (±7.10 gwater/ m2/hr). A raised TEWL at 2 mont...
متن کاملEvaluation of skin barrier function in allergic contact dermatitis and atopic dermatitis using method of the continuous TEWL measurement.
PURPOSE The aim of study was to determine usefulness of the method of continuous TEWL measurement in the evaluation of skin barrier function in physiological conditions and in allergic contact dermatitis (ACD) and atopic dermatitis (AD). MATERIAL AND METHODS Study was conducted on a group of 86 persons: 48 patients with allergic contact dermatitis, 18 with atopic dermatitis and 20 healthy ind...
متن کاملEffect of Skin-To-Skin Contact on Preterm Infant Skin Barrier Function and Hospital-Acquired Infection
BACKGROUND The preterm infants' skin is structurally and functionally immature at birth because of immature stratum corneum barrier function, leading to problems with fluid loses, thermoregulation, and infection. Two parameters of barrier function can be non-invasively assessed: Stratum Corneum Hydration (SCH) and Transepidermal Water Loss (TEWL). Skin-to-Skin Care (SSC) is the proposed indepen...
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